Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
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Author / Creator
De, Suman , Wirthensohn, David C. , Flagmeier, Patrick , Hughes, Craig , Aprile, Francesco A. , Ruggeri, Francesco S. , Whiten, Daniel R. , Emin, Derya , Xia, Zengjie , Varela, Juan A. , Sormanni, Pietro , Kundel, Franziska , Knowles, Tuomas P. J. , Dobson, Christopher M. , Bryant, Clare , Vendruscolo, Michele and Klenerman, David
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer’s disease. Here, we find that soluble aggregates formed at different stages of the aggregation process of amyloid beta (Aβ42) induce the disruption of lipid...
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Full title
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
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TN_cdi_doaj_primary_oai_doaj_org_article_dda94a3ed6064b0ba41892597f9160ae
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_dda94a3ed6064b0ba41892597f9160ae
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09477-3
