White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Contents
The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer's disease. During middle age, cognitively healthy APOE-ε4 carriers already show several brain alterations that resemble those of Alzheimer's disease (AD), but to a subtler degree. These include microstructural white matter (WM) changes that...
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Full title
White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
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TN_cdi_doaj_primary_oai_doaj_org_article_deeb308a4fec42c5a252aee6fd117ebb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_deeb308a4fec42c5a252aee6fd117ebb
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-018-0375-x
