ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between...
ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
ATR kinase activity slows replication forks and prevents origin firing in damaged cells. Here we describe proteomic analyses that identified mechanisms through which ATR kinase inhibitors induce unscheduled origin firing in undamaged cells. ATR-Chk1 inhibitor-induced origin firing is mediated by Cdc7 kinase through previously undescribed phosphoryl...
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Full title
ATR kinase inhibition induces unscheduled origin firing through a Cdc7-dependent association between GINS and And-1
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TN_cdi_doaj_primary_oai_doaj_org_article_e06d11873a0341e4bb21a45631b70175
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e06d11873a0341e4bb21a45631b70175
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01401-x
