Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy
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Author / Creator
Nelson, Barbara S. , Lin, Lin , Kremer, Daniel M. , Sousa, Cristovão M. , Cotta-Ramusino, Cecilia , Myers, Amy , Ramos, Johanna , Gao, Tina , Kovalenko, Ilya , Wilder-Romans, Kari , Dresser, Joseph , Davis, Mary , Lee, Ho-Joon , Nwosu, Zeribe C. , Campit, Scott , Mashadova, Oksana , Nicolay, Brandon N. , Tolstyka, Zachary P. , Halbrook, Christopher J. , Chandrasekaran, Sriram , Asara, John M. , Crawford, Howard C. , Cantley, Lewis C. , Kimmelman, Alec C. , Wahl, Daniel R. and Lyssiotis, Costas A.
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Metabolic programs in cancer cells are influenced by genotype and the tissue of origin. We have previously shown that central carbon metabolism is rewired in pancreatic ductal adenocarcinoma (PDA) to support proliferation through a glutamate oxaloacetate transaminase 1 (GOT1)-dependent pathway.
We utilized a doxycycline-inducible shRNA-mediated...
Alternative Titles
Full title
Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy
Authors, Artists and Contributors
Author / Creator
Lin, Lin
Kremer, Daniel M.
Sousa, Cristovão M.
Cotta-Ramusino, Cecilia
Myers, Amy
Ramos, Johanna
Gao, Tina
Kovalenko, Ilya
Wilder-Romans, Kari
Dresser, Joseph
Davis, Mary
Lee, Ho-Joon
Nwosu, Zeribe C.
Campit, Scott
Mashadova, Oksana
Nicolay, Brandon N.
Tolstyka, Zachary P.
Halbrook, Christopher J.
Chandrasekaran, Sriram
Asara, John M.
Crawford, Howard C.
Cantley, Lewis C.
Kimmelman, Alec C.
Wahl, Daniel R.
Lyssiotis, Costas A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e08285467c004f0193e607f0286f4ab7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e08285467c004f0193e607f0286f4ab7
Other Identifiers
ISSN
2049-3002
E-ISSN
2049-3002
DOI
10.1186/s40170-019-0202-2
