Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
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Author / Creator
Zhang, Yuqi , Li, Yizeng , Thompson, Keyata N. , Stoletov, Konstantin , Yuan, Qinling , Bera, Kaustav , Lee, Se Jong , Zhao, Runchen , Kiepas, Alexander , Wang, Yao , Mistriotis, Panagiotis , Serra, Selma A. , Lewis, John D. , Valverde, Miguel A. , Martin, Stuart S. , Sun, Sean X. and Konstantopoulos, Konstantinos
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. According to the Osmotic Engine Model, polarization of NHE1 at the leading edge of confined cells facilitates water uptake, cell protrusion and motility. The physiological relevance of the Osmotic Engine Model and the identity of molecules mediating cell r...
Alternative Titles
Full title
Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_e0d59226dc564a198172e55e93cfb59f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0d59226dc564a198172e55e93cfb59f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-33683-1
