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Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0d59226dc564a198172e55e93cfb59f

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis

About this item

Full title

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2022-10, Vol.13 (1), p.6128-17, Article 6128

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. According to the Osmotic Engine Model, polarization of NHE1 at the leading edge of confined cells facilitates water uptake, cell protrusion and motility. The physiological relevance of the Osmotic Engine Model and the identity of molecules mediating cell r...

Alternative Titles

Full title

Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e0d59226dc564a198172e55e93cfb59f

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e0d59226dc564a198172e55e93cfb59f

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-022-33683-1

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