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The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid di...

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid di...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e188616ed8974641a305dd3aa2218f57

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

About this item

Full title

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2018-05, Vol.8 (1), p.7228-20, Article 7228

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

There is growing appreciation of the importance of the mechanical properties of the tumor microenvironment on disease progression. However, the role of extracellular matrix (ECM) stiffness and cellular mechanotransduction in epithelial ovarian cancer (EOC) is largely unknown. Here, we investigated the effect of substrate rigidity on various aspects...

Alternative Titles

Full title

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e188616ed8974641a305dd3aa2218f57

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e188616ed8974641a305dd3aa2218f57

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-018-25589-0

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