Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells
Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells
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Author / Creator
Stein, Andrew M. , Grupp, Stephan A. , Levine, John E. , Laetsch, Theodore W. , Pulsipher, Michael A. , Boyer, Michael W. , August, Keith J. , Levine, Bruce L. , Tomassian, Lori , Shah, Sweta , Leung, Mimi , Huang, Pai‐Hsi , Awasthi, Rakesh , Mueller, Karen Thudium , Wood, Patricia A. and June, Carl H.
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
United States: John Wiley & Sons, Inc
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Contents
Tisagenlecleucel is a chimeric antigen receptor–T cell therapy that facilitates the killing of CD19+ B cells. A model was developed for the kinetics of tisagenlecleucel and the impact of therapies for treating cytokine release syndrome (tocilizumab and corticosteroids) on expansion. Data from two phase II studies in pediatric and young adult relaps...
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Full title
Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells
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TN_cdi_doaj_primary_oai_doaj_org_article_e1eac9e64fa4445bbb240eabb2a86beb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e1eac9e64fa4445bbb240eabb2a86beb
Other Identifiers
ISSN
2163-8306
E-ISSN
2163-8306
DOI
10.1002/psp4.12388
