Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortality. However, the key cachexins that mediate cancer-induced muscle wasting remain elusive. Here, we show that tumor-released extracellular Hsp70 and Hsp90 are responsible for tumor’s capacity to induce muscle wasting. We detected high-level constitutive releas...
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Full title
Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
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TN_cdi_doaj_primary_oai_doaj_org_article_e1eba5b33bfe496a995e5d12f008fd11
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e1eba5b33bfe496a995e5d12f008fd11
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00726-x
