A phosphotyrosine switch regulates organic cation transporters
A phosphotyrosine switch regulates organic cation transporters
About this item
Full title
Author / Creator
Sprowl, Jason A. , Ong, Su Sien , Gibson, Alice A. , Hu, Shuiying , Du, Guoqing , Lin, Wenwei , Li, Lie , Bharill, Shashank , Ness, Rachel A. , Stecula, Adrian , Offer, Steven M. , Diasio, Robert B. , Nies, Anne T. , Schwab, Matthias , Cavaletti, Guido , Schlatter, Eberhard , Ciarimboli, Giuliano , Schellens, Jan H. M. , Isacoff, Ehud Y. , Sali, Andrej , Chen, Taosheng , Baker, Sharyn D. , Sparreboom, Alex and Pabla, Navjotsingh
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Membrane transporters are key determinants of therapeutic outcomes. They regulate systemic and cellular drug levels influencing efficacy as well as toxicities. Here we report a unique phosphorylation-dependent interaction between drug transporters and tyrosine kinase inhibitors (TKIs), which has uncovered widespread phosphotyrosine-mediated regulat...
Alternative Titles
Full title
A phosphotyrosine switch regulates organic cation transporters
Authors, Artists and Contributors
Author / Creator
Ong, Su Sien
Gibson, Alice A.
Hu, Shuiying
Du, Guoqing
Lin, Wenwei
Li, Lie
Bharill, Shashank
Ness, Rachel A.
Stecula, Adrian
Offer, Steven M.
Diasio, Robert B.
Nies, Anne T.
Schwab, Matthias
Cavaletti, Guido
Schlatter, Eberhard
Ciarimboli, Giuliano
Schellens, Jan H. M.
Isacoff, Ehud Y.
Sali, Andrej
Chen, Taosheng
Baker, Sharyn D.
Sparreboom, Alex
Pabla, Navjotsingh
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e23f1634f35944d0a0ca31c8bfbcf90b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e23f1634f35944d0a0ca31c8bfbcf90b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10880
