Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent m...
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
About this item
Full title
Author / Creator
Deczkowska, Aleksandra , Matcovitch-Natan, Orit , Tsitsou-Kampeli, Afroditi , Ben-Hamo, Sefi , Dvir-Szternfeld, Raz , Spinrad, Amit , Singer, Oded , David, Eyal , Winter, Deborah R. , Smith, Lucas K. , Kertser, Alexander , Baruch, Kuti , Rosenzweig, Neta , Terem, Anna , Prinz, Marco , Villeda, Saul , Citri, Ami , Amit, Ido and Schwartz, Michal
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
During ageing, microglia acquire a phenotype that may negatively affect brain function. Here we show that ageing microglial phenotype is largely imposed by interferon type I (IFN-I) chronically present in aged brain milieu. Overexpression of IFN-β in the CNS of adult wild-type mice, but not of mice lacking IFN-I receptor on their microglia, induces...
Alternative Titles
Full title
Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner
Authors, Artists and Contributors
Author / Creator
Matcovitch-Natan, Orit
Tsitsou-Kampeli, Afroditi
Ben-Hamo, Sefi
Dvir-Szternfeld, Raz
Spinrad, Amit
Singer, Oded
David, Eyal
Winter, Deborah R.
Smith, Lucas K.
Kertser, Alexander
Baruch, Kuti
Rosenzweig, Neta
Terem, Anna
Prinz, Marco
Villeda, Saul
Citri, Ami
Amit, Ido
Schwartz, Michal
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e2dc3b78b5264d47bfe7a706887e8f6c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e2dc3b78b5264d47bfe7a706887e8f6c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00769-0
