17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants in the 17q21 haploblock that alter the expression of
ORMDL3
; however, the molecular mechanisms by which these variants perturb gene expression and the cell types in which this effect is most prominent are unclear. We found several 17q21 variants overlap...
Alternative Titles
Full title
17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e3236bb261ed40f88943e91e159bc89e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e3236bb261ed40f88943e91e159bc89e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13426
