Toward the Identification of Natural Antiviral Drug Candidates against Merkel Cell Polyomavirus: Com...
Toward the Identification of Natural Antiviral Drug Candidates against Merkel Cell Polyomavirus: Computational Drug Design Approaches
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Author / Creator
Asseri, Amer H , Alam, Md Jahidul , Alzahrani, Faisal , Khames, Ahmed , Pathan, Mohammad Turhan , Abourehab, Mohammed A S , Hosawi, Salman , Ahmed, Rubaiat , Sultana, Sifat Ara , Alam, Nazia Fairooz , Alam, Nafee-Ul , Alam, Rahat , Samad, Abdus , Pokhrel, Sushil , Kim, Jin Kyu , Ahammad, Foysal , Kim, Bonglee and Tan, Shing Cheng
Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
Merkel cell carcinoma (MCC) is a rare form of aggressive skin cancer mainly caused by Merkel cell polyomavirus (MCPyV). Most MCC tumors express MCPyV large T (LT) antigens and play an important role in the growth-promoting activities of oncoproteins. Truncated LT promotes tumorigenicity as well as host cell proliferation by activating the viral rep...
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Full title
Toward the Identification of Natural Antiviral Drug Candidates against Merkel Cell Polyomavirus: Computational Drug Design Approaches
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TN_cdi_doaj_primary_oai_doaj_org_article_e387fa8076464669bfae5dfa73bfeb13
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e387fa8076464669bfae5dfa73bfeb13
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ISSN
1424-8247
E-ISSN
1424-8247
DOI
10.3390/ph15050501
