Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of...
Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Supplementation of cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA) with high concentration pyridoxal 5′-phosphate, the cofactor of vitamin B6, potentiates the cytotoxicity of FUra in a synergistic interaction mode. We report a pilot study in 13 patients with previously untreated advanced carcinoma of the digestive tract to asses...
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Pharmacologic modulation of 5-fluorouracil by folinic acid and high-dose pyridoxine for treatment of patients with digestive tract carcinomas
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TN_cdi_doaj_primary_oai_doaj_org_article_e48a6dffbe93495e979f8eb33857f074
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e48a6dffbe93495e979f8eb33857f074
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-92110-5
