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Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reve...

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reve...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4db6bdee3604f1f99762479edb0766b

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction

About this item

Full title

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction

Publisher

England: BioMed Central Ltd

Journal title

BMC cell biology, 2022-01, Vol.23 (1), p.2-2, Article 2

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

SARS-CoV-2, the causative agent of COVID-19 pandemic is a RNA virus prone to mutations. Formation of a stable binding interface between the Receptor Binding Domain (RBD) of SARS-CoV-2 Spike (S) protein and Angiotensin-Converting Enzyme 2 (ACE2) of host is pivotal for viral entry. RBD has been shown to mutate frequently during pandemic. Although, a...

Alternative Titles

Full title

Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interaction

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e4db6bdee3604f1f99762479edb0766b

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e4db6bdee3604f1f99762479edb0766b

Other Identifiers

ISSN

2661-8850

E-ISSN

2661-8850,1471-2121

DOI

10.1186/s12860-021-00403-4

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