Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer's disease
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer's disease
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Alzheimer's disease is a neurodegenerative condition associated with the accumulation of two misfolded proteins, amyloid-beta (A[Formula: see text]) and tau. We study their effect on neuronal activity, with the aim of assessing their individual and combined impact.
We use a whole-brain dynamic model to find the optimal parameters that best descr...
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Full title
Whole-brain modeling of the differential influences of amyloid-beta and tau in Alzheimer's disease
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TN_cdi_doaj_primary_oai_doaj_org_article_e6440b83b9da46238fd903843b0cbb15
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e6440b83b9da46238fd903843b0cbb15
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ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-023-01349-9
