Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synucle...
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
About this item
Full title
Author / Creator
Nielsen, Janni , Lauritsen, Johanne , Pedersen, Jannik N. , Nowak, Jan S. , Bendtsen, Malthe K. , Kleijwegt, Giulia , Lusser, Kaija , Pitarch, Laia C. , Moreno, Julián V. , Schneider, Matthias M. , Krainer, Georg , Goksøyr, Louise , Khalifé, Paul , Kaalund, Sanne Simone , Aznar, Susana , Kjærgaard, Magnus , Sereikaité, Vita , Strømgaard, Kristian , Knowles, Tuomas P. J. , Nielsen, Morten Agertoug , Sander, Adam F. , Romero-Ramos, Marina and Otzen, Daniel E.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
α-Synuclein (α-syn) accumulates as insoluble amyloid but also forms soluble α-syn oligomers (αSOs), thought to be even more cytotoxic than fibrils. To detect and block the unwanted activities of these αSOs, we have raised 30 monoclonal antibodies (mAbs) against different forms of αSOs, ranging from unmodified αSOs to species stabilized by lipid per...
Alternative Titles
Full title
Molecular properties and diagnostic potential of monoclonal antibodies targeting cytotoxic α-synuclein oligomers
Authors, Artists and Contributors
Author / Creator
Lauritsen, Johanne
Pedersen, Jannik N.
Nowak, Jan S.
Bendtsen, Malthe K.
Kleijwegt, Giulia
Lusser, Kaija
Pitarch, Laia C.
Moreno, Julián V.
Schneider, Matthias M.
Krainer, Georg
Goksøyr, Louise
Khalifé, Paul
Kaalund, Sanne Simone
Aznar, Susana
Kjærgaard, Magnus
Sereikaité, Vita
Strømgaard, Kristian
Knowles, Tuomas P. J.
Nielsen, Morten Agertoug
Sander, Adam F.
Romero-Ramos, Marina
Otzen, Daniel E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e6e9d9eb66fb4db88fab4f91ceef8060
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e6e9d9eb66fb4db88fab4f91ceef8060
Other Identifiers
ISSN
2373-8057
E-ISSN
2373-8057
DOI
10.1038/s41531-024-00747-6
