Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis
Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulators down regulate this exaggerated proinflammatory response following LPS/ATP stimulation. In vitro ap...
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Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis
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TN_cdi_doaj_primary_oai_doaj_org_article_e72e404e8886401f9e9b651bbc12b5a4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e72e404e8886401f9e9b651bbc12b5a4
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.54556
