USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
About this item
Full title
Author / Creator
Xiong, Wenjun , Gao, Xueliang , Zhang, Tiantian , Jiang, Baishan , Hu, Ming-Ming , Bu, Xia , Gao, Yang , Zhang, Lin-Zhou , Xiao, Bo-Lin , He, Chuan , Sun, Yishuang , Li, Haiou , Shi, Jie , Xiao, Xiangling , Xiang, Bolin , Xie, Conghua , Chen, Gang , Zhang, Haojian , Wei, Wenyi , Freeman, Gordon J. , Shu, Hong-Bing , Wang, Haizhen and Zhang, Jinfang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Anti-PD-1/PD-L1 immunotherapy has achieved impressive therapeutic outcomes in patients with multiple cancer types. However, the underlined molecular mechanism(s) for moderate response rate (15–25%) or resistance to PD-1/PD-L1 blockade remains not completely understood. Here, we report that inhibiting the deubiquitinase, USP8, significantly enhances...
Alternative Titles
Full title
USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy
Authors, Artists and Contributors
Author / Creator
Gao, Xueliang
Zhang, Tiantian
Jiang, Baishan
Hu, Ming-Ming
Bu, Xia
Gao, Yang
Zhang, Lin-Zhou
Xiao, Bo-Lin
He, Chuan
Sun, Yishuang
Li, Haiou
Shi, Jie
Xiao, Xiangling
Xiang, Bolin
Xie, Conghua
Chen, Gang
Zhang, Haojian
Wei, Wenyi
Freeman, Gordon J.
Shu, Hong-Bing
Wang, Haizhen
Zhang, Jinfang
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e769071990584a6aa031c02542686ae3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e769071990584a6aa031c02542686ae3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29401-6
