The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane...
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
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England: eLife Science Publications, Ltd
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English
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Publisher
England: eLife Science Publications, Ltd
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Contents
The selective autophagy pathways of xenophagy and mitophagy are initiated when the adaptor NDP52 recruits the ULK1 complex to autophagic cargo. Hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS) was used to map the membrane and NDP52 binding sites of the ULK1 complex to unique regions of the coiled coil of the FIP200 subunit. Electro...
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Full title
The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
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TN_cdi_doaj_primary_oai_doaj_org_article_e786f6f75aaa4c64a93f920762d965ee
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e786f6f75aaa4c64a93f920762d965ee
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.59099
