N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membr...
N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β release. In contrast, we report that although N-GSDMD is required for IL-1β secretion in NLRP3-activ...
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N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis
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TN_cdi_doaj_primary_oai_doaj_org_article_e8657a099f0941af8558ca645f8e6b29
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8657a099f0941af8558ca645f8e6b29
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16043-9
