Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease
Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Lipocalin-2 (LCN2) is an acute-phase secretory molecule significantly upregulated in various neuroinflammatory and demyelinating conditions. Krabbe disease (KD) is a neurodegenerative lysosomal disorder caused by a galactosylceramidase (GALC) deficiency, accumulating cytotoxic psychosine in nervous systems, and subsequent neuroinflammation. Here, w...
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Ablation of lipocalin-2 reduces neuroinflammation in a mouse model of Krabbe disease
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TN_cdi_doaj_primary_oai_doaj_org_article_e8968fbb86864e12864baafe3b85e366
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8968fbb86864e12864baafe3b85e366
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-82927-1
