A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translati...
A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Nascent polypeptides can induce ribosome stalling, regulating downstream genes. Stalling of ErmBL peptide translation in the presence of the macrolide antibiotic erythromycin leads to resistance in
Streptococcus sanguis
. To reveal this stalling mechanism we obtained 3.6-Å-resolution cryo-EM structures of ErmBL-stalled ribosomes with erythrom...
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A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest
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TN_cdi_doaj_primary_oai_doaj_org_article_e950afdd22974cc8a096e6e992509d62
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e950afdd22974cc8a096e6e992509d62
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12026
