Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Small heat shock proteins (sHSPs) are a class of oligomeric molecular chaperones that limit protein aggregation. However, it is often not clear where sHSPs bind on their client proteins or how these protein-protein interactions (PPIs) are regulated. Here, we map the PPIs between human Hsp27 and the microtubule-associated protein tau (MAPT/tau). We...
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Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau
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TN_cdi_doaj_primary_oai_doaj_org_article_ea828c6ee26840cd8de08621cb5f0b7d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ea828c6ee26840cd8de08621cb5f0b7d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07012-4
