Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels
Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels
About this item
Full title
Author / Creator
Liu, Nan , Yang, Yaxiong , Ge, Lin , Liu, Min , Colecraft, Henry M and Liu, Xiaodong
Publisher
Cambridge: eLife Sciences Publications Ltd
Journal title
Language
English
Formats
Publication information
Publisher
Cambridge: eLife Sciences Publications Ltd
Subjects
More information
Scope and Contents
Contents
Inhibitions and antagonists of L-type Ca2+ channels are important to both research and therapeutics. Here, we report C-terminus mediated inhibition (CMI) for CaV1.3 that multiple motifs coordinate to tune down Ca2+ current and Ca2+ influx toward the lower limits determined by end-stage CDI (Ca2+-dependent inactivation). Among IQV (preIQ3-IQ domain)...
Alternative Titles
Full title
Cooperative and acute inhibition by multiple C-terminal motifs of L-type Ca2+ channels
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ebb2dc1b010240058ed6b5639c4e8ad0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ebb2dc1b010240058ed6b5639c4e8ad0
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.21989
