Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gatin...
Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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In contrast to most voltage-gated ion channels, hyperpolarization- and cAMP gated (HCN) ion channels open on hyperpolarization. Structure-function studies show that the voltage-sensor of HCN channels are unique but the mechanisms that determine gating polarity remain poorly understood. All-atom molecular dynamics simulations (~20 μs) of HCN1 channe...
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Full title
Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
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TN_cdi_doaj_primary_oai_doaj_org_article_ec37f2fe477a4a0880de9334fca6afd9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec37f2fe477a4a0880de9334fca6afd9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.53400
