Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translatio...
Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The number of tRNA isodecoders has increased dramatically in mammals, but the specific molecular and physiological reasons for this expansion remain elusive. To address this fundamental question we used CRISPR editing to knockout the seven-membered phenylalanine tRNA gene family in mice, both individually and combinatorially. Using ATAC-Seq, RNA-se...
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Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation
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TN_cdi_doaj_primary_oai_doaj_org_article_ec64d6bde2394ea6ac0ddbefcb5e127d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec64d6bde2394ea6ac0ddbefcb5e127d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37843-9
