Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse...
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
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Author / Creator
Tullo, Stephanie , Park, Janice , Gallino, Daniel , Park, Megan , Mar, Kristie , Novikov, Vladislav , Sandoval Contreras, Rodrigo , Patel, Raihaan , del Cid-Pellitero, Esther , Fon, Edward A. , Luo, Wen , Shlaifer, Irina , Durcan, Thomas M. , Prado, Marco A. M. , Prado, Vania F. , Devenyi, Gabriel A. and Chakravarty, M. Mallar
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Despite known sex differences in human synucleinopathies such as Parkinson’s disease, the impact of sex on alpha-synuclein pathology in mouse models has been largely overlooked. To address this need, we examine sex differences in whole brain signatures of neurodegeneration due to aSyn toxicity in the M83 mouse model using longitudinal magnetic reso...
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Full title
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils
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TN_cdi_doaj_primary_oai_doaj_org_article_ecc99a6ab19948dc86855c26303c0047
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ecc99a6ab19948dc86855c26303c0047
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-025-07680-1
