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Structural basis for hyperpolarization-dependent opening of human HCN1 channel

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed21ec411b92467f8993849f5cda3aa8

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

About this item

Full title

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

Publisher

London: Nature Publishing Group UK

Journal title

Nature communications, 2024-06, Vol.15 (1), p.5216-13, Article 5216

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion channels, the HCN and related plant ion channels activate upon membrane hyperpolarization. Although functional studies have identi...

Alternative Titles

Full title

Structural basis for hyperpolarization-dependent opening of human HCN1 channel

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_ed21ec411b92467f8993849f5cda3aa8

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed21ec411b92467f8993849f5cda3aa8

Other Identifiers

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-024-49599-x

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