726 SRF114 is a fully human, CCR8 selective IgG1 antibody that induces destruction of tumor Tregs th...
726 SRF114 is a fully human, CCR8 selective IgG1 antibody that induces destruction of tumor Tregs through ADCC
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London: BMJ Publishing Group LTD
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English
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London: BMJ Publishing Group LTD
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BackgroundT regulatory cells (Tregs) are potent suppressors of immune activation in the periphery and tumor microenvironment (TME). Tumor-infiltrating Tregs have also been associated with resistance to cancer therapies. Loss of peripheral Tregs can lead to widespread autoimmunity and tissue destruction; therefore, specifically depleting tumor Tregs...
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Full title
726 SRF114 is a fully human, CCR8 selective IgG1 antibody that induces destruction of tumor Tregs through ADCC
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TN_cdi_doaj_primary_oai_doaj_org_article_ed7f6d75d4c8448fa6d8083af15bf784
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed7f6d75d4c8448fa6d8083af15bf784
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E-ISSN
2051-1426
DOI
10.1136/jitc-2020-SITC2020.0726
