Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters
Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters
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Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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In this study, we delve into the impact of genotoxic anticancer drug treatment on the chromatin structure of human cells, with a particular focus on the effects of doxorubicin. Using Hi-C, ChIP-seq, and RNA-seq, we explore the changes in chromatin architecture brought about by doxorubicin and ICRF193. Our results indicate that physiologically relev...
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Doxorubicin Changes the Spatial Organization of the Genome around Active Promoters
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TN_cdi_doaj_primary_oai_doaj_org_article_edab11f3c9e34c75851868cad695b089
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_edab11f3c9e34c75851868cad695b089
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells12152001
