Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signali...
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
About this item
Full title
Author / Creator
Walker, Keenan A , An, Yang , Moghekar, Abhay , Moaddel, Ruin , Duggan, Michael R , Peng, Zhongsheng , Tian, Qu , Pilling, Luke C , Drouin, Shannon M , Espeland, Mark A , Rapp, Stephen R , Hayden, Kathleen M , Shadyab, Aladdin H , Casanova, Ramon , Thambisetty, Madhav , Rapp, Peter R , Kapogiannis, Dimitrios , Ferrucci, Luigi and Resnick, Susan M
Publisher
England: BioMed Central
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central
Subjects
More information
Scope and Contents
Contents
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer's disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechanisms that allow some APOEε4 carriers to maintain normal cognitive functioning in older adulthood.
APOEε4 carriers and APO...
Alternative Titles
Full title
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Authors, Artists and Contributors
Author / Creator
An, Yang
Moghekar, Abhay
Moaddel, Ruin
Duggan, Michael R
Peng, Zhongsheng
Tian, Qu
Pilling, Luke C
Drouin, Shannon M
Espeland, Mark A
Rapp, Stephen R
Hayden, Kathleen M
Shadyab, Aladdin H
Casanova, Ramon
Thambisetty, Madhav
Rapp, Peter R
Kapogiannis, Dimitrios
Ferrucci, Luigi
Resnick, Susan M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ee7fd18cf0994326a5954b2b904a2e34
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee7fd18cf0994326a5954b2b904a2e34
Other Identifiers
ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-024-00772-2
