UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of Alzheimer’s disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting neurodegeneration in AD patients. To identify suppressors of
tau
-mediated AD, we perform a screen using a microRNA (miR) library in
Drosophila
and identify...
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Full title
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
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TN_cdi_doaj_primary_oai_doaj_org_article_ee8a7f6a151f4e33bd0f9accda17a866
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee8a7f6a151f4e33bd0f9accda17a866
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23597-9
