Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
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Author / Creator
Wei, Hudie , Qu, Lingzhi , Dai, Shuyan , Li, Yun , Wang, Haolan , Feng, Yilu , Chen, Xiaojuan , Jiang, Longying , Guo, Ming , Li, Jun , Chen, Zhuchu , Chen, Lin , Zhang, Ye and Chen, Yongheng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by interacting with and antagonizing the anti-apoptotic proteins BCL-xL and BCL-2. However, the mechanisms by which p53 induces mitochondrial apoptosis remain elusive. Here, we report a 2.5 Å cryst...
Alternative Titles
Full title
Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_eee86fb8caf449e7a93cc5a90e776ac6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eee86fb8caf449e7a93cc5a90e776ac6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22655-6
