HCN4 channels sense temperature and determine heart rate responses to heat
HCN4 channels sense temperature and determine heart rate responses to heat
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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The
h
yperpolarization-activated
c
yclic
n
ucleotide-gated ion channel 4 (HCN4) current increases due to cAMP binding and is well-recognized to contribute to adrenergically driven heart rate acceleration. HCN4 current also increases with heat by an unknown mechanism(s). We use thermodynamical and homology computational modeling, s...
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HCN4 channels sense temperature and determine heart rate responses to heat
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TN_cdi_doaj_primary_oai_doaj_org_article_efe8eee727f74866ac4ab4d3f7497287
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_efe8eee727f74866ac4ab4d3f7497287
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-57358-9
