Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patien...
Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patients with advanced solid tumors (ARTISTRY-1)
About this item
Full title
Author / Creator
Vaishampayan, Ulka N , Muzaffar, Jameel , Winer, Ira , Rosen, Seth D , Hoimes, Christoper J , Chauhan, Aman , Spreafico, Anna , Lewis, Karl D , Bruno, Debora S , Dumas, Olivier , McDermott, David F , Strauss, James F , Chu, Quincy S , Gilbert, Lucy , Chaudhry, Arvind , Calvo, Emiliano , Dalal, Rita , Boni, Valentina , Ernstoff, Marc S and Velcheti, Vamsidhar
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd
Subjects
More information
Scope and Contents
Contents
BackgroundNemvaleukin alfa (nemvaleukin, ALKS 4230) is a novel, engineered cytokine that selectively binds to the intermediate-affinity interleukin-2 receptor, preferentially activating CD8+ T cells and natural killer cells, with minimal expansion of regulatory T cells, thereby mitigating the risk of toxicities associated with high-affinity interle...
Alternative Titles
Full title
Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patients with advanced solid tumors (ARTISTRY-1)
Authors, Artists and Contributors
Author / Creator
Muzaffar, Jameel
Winer, Ira
Rosen, Seth D
Hoimes, Christoper J
Chauhan, Aman
Spreafico, Anna
Lewis, Karl D
Bruno, Debora S
Dumas, Olivier
McDermott, David F
Strauss, James F
Chu, Quincy S
Gilbert, Lucy
Chaudhry, Arvind
Calvo, Emiliano
Dalal, Rita
Boni, Valentina
Ernstoff, Marc S
Velcheti, Vamsidhar
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_effa100105de4e66b831c7e9c39c98ff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_effa100105de4e66b831c7e9c39c98ff
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2024-010143
