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ArticlesPeer ReviewedFull Text
Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity
Author / Creator:Cindy Yang, S. Y. ; Lien, Scott C. ; Wang, Ben X. ; Clouthier, Derek L. ; Hanna, Youstina ; Cirlan, Iulia ; Zhu, Kelsey ; Bruce, Jeffrey P. ; El Ghamrasni, Samah ; Iafolla, Marco A. J. ; Oliva, Marc ; Hansen, Aaron R. ; Spreafico, Anna ; Bedard, Philippe L. ; Lheureux, Stephanie ; Razak, Albiruni ; Speers, Vanessa ; Berman, Hal K. ; Aleshin, Alexey ; Haibe-Kains, Benjamin ; Brooks, David G. ; McGaha, Tracy L. ; Butler, Marcus O. ; Bratman, Scott V. ; Ohashi, Pamela S. ; Siu, Lillian L. ; Pugh, Trevor J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-08, Vol.12 (1), p.5137-15, Article 5137
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Extracellular Vesicles and Their Applications in Tumor Diagnostics and Immunotherapy
Author / Creator:Strum, Scott ; Evdokimova, Valentina ; Radvanyi, Laszlo ; Spreafico, Anna
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2024-12, Vol.13 (23), p.2031
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Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy
Author / Creator:Cunningham, Morven ; Iafolla, Marco ; Kanjanapan, Yada ; Cerocchi, Orlando ; Butler, Marcus ; Siu, Lillian L. ; Bedard, Philippe L. ; Ross, Kendra ; Hansen, Bettina ; Spreafico, Anna ; Feld, Jordan J.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-06, Vol.16 (6), p.e0253070
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Promising and Minimally Invasive Biomarkers: Targeting Melanoma
Author / Creator:Spiliopoulou, Pavlina ; Holanda Lopes, Carlos Diego ; Spreafico, Anna
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2023-12, Vol.13 (1), p.19
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Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient
Author / Creator:Lien, Scott C. ; Ly, Dalam ; Yang, S. Y. Cindy ; Wang, Ben X. ; Clouthier, Derek L. ; St. Paul, Michael ; Gadalla, Ramy ; Noamani, Babak ; Garcia-Batres, Carlos R. ; Boross-Harmer, Sarah ; Bedard, Philippe L. ; Pugh, Trevor J. ; Spreafico, Anna ; Hirano, Naoto ; Razak, Albiruni R. A. ; Ohashi, Pamela S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-02, Vol.15 (1), p.1094-1094, Article 1094
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Evaluation of the patient experience of symptomatic adverse events on Phase I clinical trials using PRO-CTCAE
Author / Creator:Watson, Geoffrey A. ; Veitch, Zachary W. ; Shepshelovich, Daniel ; Liu, Zhihui Amy ; Spreafico, Anna ; Abdul Razak, Albiruni R. ; Bedard, Philippe L. ; Siu, Lillian L. ; Minasian, Lori ; Hansen, Aaron R.
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2022-11, Vol.127 (9), p.1629-1635
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Dupilumab as a treatment for cutaneous immune-related adverse events induced by immune checkpoint inhibitors: A case series and review of the literature
Author / Creator:Fournier, Cynthia ; Hirsch, Ian ; Spreafico, Anna ; Butler, Marcus Otho ; Dhani, Neesha ; Sauder, Maxwell Benjamin
Publisher:London, England: SAGE Publications
Journal title:SAGE open medical case reports, 2023-01, Vol.11
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A Canadian Perspective on Systemic Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma
Author / Creator:Spreafico, Anna ; Winquist, Eric ; Ho, Cheryl ; O’Sullivan, Brian ; Bouganim, Nathaniel ; Chua, Neil ; Doucette, Sarah ; Siu, Lillian L. ; Hao, Desiree
Publisher:Switzerland: MDPI AG
Journal title:Current oncology (Toronto), 2025-01, Vol.32 (1), p.48
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Longitudinal efficacy and toxicity of SARS-CoV-2 vaccination in cancer patients treated with immunotherapy
Author / Creator:Spiliopoulou, Pavlina ; Janse van Rensburg, Helena J ; Avery, Lisa ; Kulasingam, Vathany ; Razak, Albiruni ; Bedard, Philippe ; Hansen, Aaron ; Chruscinski, Andrzej ; Wang, Ben ; Kulikova, Maria ; Chen, Rachel ; Speers, Vanessa ; Nguyen, Alisa ; Lee, Jasmine ; Coburn, Bryan ; Spreafico, Anna ; Siu, Lillian L
Publisher:London: Springer Nature B.V
Journal title:Cell death & disease, 2023-01, Vol.14 (1), p.49
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Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-β monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors
Author / Creator:Bauer, Todd M ; Santoro, Armando ; Lin, Chia-Chi ; Garrido-Laguna, Ignacio ; Joerger, Markus ; Greil, Richard ; Spreafico, Anna ; Yau, Thomas ; Goebeler, Maria-Elisabeth ; Hütter-Krönke, Marie Luise ; Perotti, Antonella ; Juif, Pierre-Eric ; Lu, Darlene ; Barys, Louise ; Cremasco, Viviana ; Pelletier, Marc ; Evans, Helen ; Fabre, Claire ; Doi, Toshikiko
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2023-11, Vol.11 (11), p.e007353
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An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors
Author / Creator:Taylor, Kirsty ; Loo Yau, Helen ; Chakravarthy, Ankur ; Wang, Ben ; Shen, Shu Yi ; Ettayebi, Ilias ; Ishak, Charles A ; Bedard, Philippe L ; Abdul Razak, Albiruni ; R Hansen, Aaron ; Spreafico, Anna ; Cescon, Dave ; Butler, Marcus O ; Oza, Amit M ; Lheureux, Stephanie ; Stjepanovic, Neda ; Van As, Brendan ; Boross-Harmer, Sarah ; Wang, Lisa ; Pugh, Trevor J ; Ohashi, Pamela S ; Siu, Lillian L ; De Carvalho, Daniel D
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2020-08, Vol.8 (2), p.e000883
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Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT)
Author / Creator:Genta, Sofia ; Lajkosz, Katherine ; Yee, Noelle R. ; Spiliopoulou, Pavlina ; Heirali, Alya ; Hansen, Aaron R. ; Siu, Lillian L. ; Saibil, Sam ; Stayner, Lee-Anne ; Yanekina, Maryia ; Sauder, Maxwell B. ; Keshavarzi, Sareh ; Salawu, Abdulazeez ; Vornicova, Olga ; Butler, Marcus O. ; Bedard, Philippe L. ; Razak, Albiruni R. Abdul ; Rottapel, Robert ; Chruscinski, Andrzej ; Coburn, Bryan ; Spreafico, Anna
Publisher:London: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2023-10, Vol.42 (1), p.1-276, Article 276
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Biologic subtypes of melanoma predict survival benefit of combination anti-PD1+anti-CTLA4 immune checkpoint inhibitors versus anti-PD1 monotherapy
Author / Creator:Rose, April A N ; Armstrong, Susan M ; Hogg, David ; Butler, Marcus O ; Saibil, Samuel D ; Arteaga, Diana P ; Pimentel Muniz, Thiago ; Kelly, Deirdre ; Ghazarian, Danny ; King, Ian ; Kamil, Zaid Saeed ; Ross, Kendra ; Spreafico, Anna
Publisher:England: BMJ Publishing Group LTD
Journal title:Journal for immunotherapy of cancer, 2021-01, Vol.9 (1), p.e001642
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Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study
Author / Creator:Oliva, Marc ; Chepeha, Douglas ; Araujo, Daniel V ; Diaz-Mejia, J. Javier ; Olson, Peter ; Prawira, Amy ; Spreafico, Anna ; Bratman, Scott V ; Shek, Tina ; de Almeida, John ; R Hansen, Aaron ; Hope, Andrew ; Goldstein, David ; Weinreb, Ilan ; Smith, Stephen ; Perez-Ordoñez, Bayardo ; Irish, Jonathan ; Torti, Dax ; Bruce, Jeffrey P. ; Wang, Ben X. ; Fortuna, Anthony ; Pugh, Trevor J. ; Der-Torossian, Hirak ; Shazer, Ronald ; Attanasio, Nickolas ; Au, Qingyan ; Tin, Antony ; Feeney, Jordan ; Sethi, Himanshu ; Aleshin, Alexey ; Chen, Isan ; Siu, Lillian
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2021-10, Vol.9 (10), p.e003476
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Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS‐001 clinical trial
Author / Creator:Hernando‐Calvo, Alberto ; Malone, Eoghan ; Day, Daphne ; Prawira, Amy ; Weinreb, Ilan ; Yang, S. Y. Cindy ; Wong, Horace ; Rodriguez, Angela ; Jennings, Sarah ; Eliason, Anneli ; Wang, Lisa ; Spreafico, Anna ; Siu, Lillian L. ; Hansen, Aaron R.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2023-10, Vol.12 (20), p.20299-20310
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Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patients with advanced solid tumors (ARTISTRY-1)
Author / Creator:Vaishampayan, Ulka N ; Muzaffar, Jameel ; Winer, Ira ; Rosen, Seth D ; Hoimes, Christoper J ; Chauhan, Aman ; Spreafico, Anna ; Lewis, Karl D ; Bruno, Debora S ; Dumas, Olivier ; McDermott, David F ; Strauss, James F ; Chu, Quincy S ; Gilbert, Lucy ; Chaudhry, Arvind ; Calvo, Emiliano ; Dalal, Rita ; Boni, Valentina ; Ernstoff, Marc S ; Velcheti, Vamsidhar
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2024-11, Vol.12 (11), p.e010143
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First-in-human phase I study of the OX40 agonist GSK3174998 with or without pembrolizumab in patients with selected advanced solid tumors (ENGAGE-1)
Author / Creator:Postel-Vinay, Sophie ; Lam, Vincent K ; Ros, Willeke ; Bauer, Todd M ; Hansen, Aaron R ; Cho, Daniel C ; Stephen Hodi, F ; Schellens, Jan H M ; Litton, Jennifer K ; Aspeslagh, Sandrine ; Autio, Karen A ; Opdam, Frans L ; McKean, Meredith ; Somaiah, Neeta ; Champiat, Stephane ; Altan, Mehmet ; Spreafico, Anna ; Rahma, Osama ; Paul, Elaine M ; Ahlers, Christoph M ; Zhou, Helen ; Struemper, Herbert ; Gorman, Shelby A ; Watmuff, Maura ; Yablonski, Kaitlin M ; Yanamandra, Niranjan ; Chisamore, Michael J ; Schmidt, Emmett V ; Hoos, Axel ; Marabelle, Aurelien ; Weber, Jeffrey S ; Heymach, John V
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2023-03, Vol.11 (3), p.e005301
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Cancer patients’ experiences with immune checkpoint modulators: A qualitative study
Author / Creator:Ala‐Leppilampi, Kari ; Baker, Natalie A. ; McKillop, Chris ; Butler, Marcus O. ; Siu, Lillian L. ; Spreafico, Anna ; Abdul Razak, Albiruni R. ; Joshua, Anthony M. ; Hogg, David ; Bedard, Philippe L. ; Leighl, Natasha ; Oza, Amit M. ; Parsons, Janet A. ; Hansen, Aaron R.
Publisher:United States: John Wiley & Sons, Inc
Journal title:Cancer medicine (Malden, MA), 2020-05, Vol.9 (9), p.3015-3022
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Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction
Author / Creator:Voon, Pei Jye ; Chen, Eric X. ; Chen, Helen X. ; Lockhart, Albert C. ; Sahebjam, Solmaz ; Kelly, Karen ; Vaishampayan, Ulka N. ; Subbiah, Vivek ; Razak, Albiruni R. ; Renouf, Daniel J. ; Hotte, Sebastien J. ; Singh, Arti ; Bedard, Philippe L. ; Hansen, Aaron R. ; Ivy, S. Percy ; Wang, Lisa ; Stayner, Lee-Anne ; Siu, Lillian L. ; Spreafico, Anna
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2022-02, Vol.41 (1), p.51-15, Article 51
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Microbial Ecosystem Therapeutics 4 (MET4) elicits treatment-specific IgG responses associated with changes in gut microbiota in immune checkpoint inhibitor recipients with advanced solid tumors
Author / Creator:Wong, Matthew K ; Boukhaled, Giselle M ; Armstrong, Eric ; Liu, Rachel ; Heirali, Alya A ; Yee, Noelle R ; Tsang, Jinny ; Spiliopoulou, Pavlina ; Schneeberger, Pierre H H ; Wang, Ben X ; Cochrane, Kyla ; Sherriff, Keith ; Allen-Vercoe, Emma ; Siu, Lillian L ; Spreafico, Anna ; Coburn, Bryan
Publisher:England: BMJ Publishing Group Ltd
Journal title:Journal for immunotherapy of cancer, 2025-03, Vol.13 (3), p.e010681
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Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity

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Extracellular Vesicles and Their Applications in Tumor Diagnostics and Immunotherapy

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Evaluation of liver enzyme elevations and hepatotoxicity in patients treated with checkpoint inhibitor immunotherapy

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Promising and Minimally Invasive Biomarkers: Targeting Melanoma

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Tumor reactive γδ T cells contribute to a complete response to PD-1 blockade in a Merkel cell carcinoma patient

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Evaluation of the patient experience of symptomatic adverse events on Phase I clinical trials using PRO-CTCAE

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Dupilumab as a treatment for cutaneous immune-related adverse events induced by immune checkpoint inhibitors: A case series and review of the literature

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A Canadian Perspective on Systemic Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma

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Longitudinal efficacy and toxicity of SARS-CoV-2 vaccination in cancer patients treated with immunotherapy

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Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-β monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors

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An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors

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Autoimmune PaneLs as PrEdictors of Toxicity in Patients TReated with Immune Checkpoint InhibiTors (ALERT)

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Biologic subtypes of melanoma predict survival benefit of combination anti-PD1+anti-CTLA4 immune checkpoint inhibitors versus anti-PD1 monotherapy

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Antitumor immune effects of preoperative sitravatinib and nivolumab in oral cavity cancer: SNOW window-of-opportunity study

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Selinexor for the treatment of recurrent or metastatic salivary gland tumors: Results from the GEMS‐001 clinical trial

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Nemvaleukin alfa, a modified interleukin-2 cytokine, as monotherapy and with pembrolizumab in patients with advanced solid tumors (ARTISTRY-1)

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First-in-human phase I study of the OX40 agonist GSK3174998 with or without pembrolizumab in patients with selected advanced solid tumors (ENGAGE-1)

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Cancer patients’ experiences with immune checkpoint modulators: A qualitative study

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Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction

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Microbial Ecosystem Therapeutics 4 (MET4) elicits treatment-specific IgG responses associated with changes in gut microbiota in immune checkpoint inhibitor recipients with advanced solid tumors

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