Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo D...
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
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Author / Creator
Gao, Linfeng , Emperle, Max , Guo, Yiran , Grimm, Sara A. , Ren, Wendan , Adam, Sabrina , Uryu, Hidetaka , Zhang, Zhi-Min , Chen, Dongliang , Yin, Jiekai , Dukatz, Michael , Anteneh, Hiwot , Jurkowska, Renata Z. , Lu, Jiuwei , Wang, Yinsheng , Bashtrykov, Pavel , Wade, Paul A. , Wang, Gang Greg , Jeltsch, Albert and Song, Jikui
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a...
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Full title
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
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TN_cdi_doaj_primary_oai_doaj_org_article_effe2dab19bf4176b1b1739202fca190
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_effe2dab19bf4176b1b1739202fca190
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17109-4
