Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
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Author / Creator
Feng, Qiang , Liu, Zhida , Yu, Xuexin , Huang, Tongyi , Chen, Jiahui , Wang, Jian , Wilhelm, Jonathan , Li, Suxin , Song, Jiwon , Li, Wei , Sun, Zhichen , Sumer, Baran D. , Li, Bo , Fu, Yang-Xin and Gao, Jinming
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Lactate is a key metabolite produced from glycolytic metabolism of glucose molecules, yet it also serves as a primary carbon fuel source for many cell types. In the tumor-immune microenvironment, effect of lactate on cancer and immune cells can be highly complex and hard to decipher, which is further confounded by acidic protons, a co-product of gl...
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Full title
Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity
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TN_cdi_doaj_primary_oai_doaj_org_article_f046c8ae08fc4d8a94ca232b1d378b19
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f046c8ae08fc4d8a94ca232b1d378b19
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32521-8
