Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger...
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
About this item
Full title
Author / Creator
Aykul, Senem , Corpina, Richard A , Goebel, Erich J , Cunanan, Camille J , Dimitriou, Alexandra , Kim, Hyon Jong , Zhang, Qian , Rafique, Ashique , Leidich, Raymond , Wang, Xin , McClain, Joyce , Jimenez, Johanna , Nannuru, Kalyan C , Rothman, Nyanza J , Lees-Shepard, John B , Martinez-Hackert, Erik , Murphy, Andrew J , Thompson, Thomas B , Economides, Aris N and Idone, Vincent
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publication information
Publisher
England: eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unexplored. The genetic disorder fibrodysplasia ossificans progressiva (FOP) provides a unique window in...
Alternative Titles
Full title
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
Authors, Artists and Contributors
Author / Creator
Corpina, Richard A
Goebel, Erich J
Cunanan, Camille J
Dimitriou, Alexandra
Kim, Hyon Jong
Zhang, Qian
Rafique, Ashique
Leidich, Raymond
Wang, Xin
McClain, Joyce
Jimenez, Johanna
Nannuru, Kalyan C
Rothman, Nyanza J
Lees-Shepard, John B
Martinez-Hackert, Erik
Murphy, Andrew J
Thompson, Thomas B
Economides, Aris N
Idone, Vincent
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f046d1441e0d4e23a1f1b1baf6223516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f046d1441e0d4e23a1f1b1baf6223516
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.54582
