Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulati...
Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
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Author / Creator
Jiang, Shi-You , Li, Hui , Tang, Jing-Jie , Wang, Jie , Luo, Jie , Liu, Bing , Wang, Jin-Kai , Shi, Xiong-Jie , Cui, Hai-Wei , Tang, Jie , Yang, Fan , Qi, Wei , Qiu, Wen-Wei and Song, Bao-Liang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Statins are inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis, and have been clinically used to treat cardiovascular disease. However, a paradoxical increase of reductase protein following statin treatment may attenuate the effect and increase the side effects. Here we present a previously unexplored strategy to...
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Full title
Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f04e0e5aaf444149a5e2dbbc5d38dc34
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f04e0e5aaf444149a5e2dbbc5d38dc34
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07590-3
