Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility
Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Respiratory complex I is a major cellular energy transducer located in the inner mitochondrial membrane. Its inhibition by rotenone, a natural isoflavonoid, has been used for centuries by indigenous peoples to aid in fishing and, more recently, as a broad-spectrum pesticide or even a possible anticancer therapeutic. Unraveling the molecular mechani...
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Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility
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TN_cdi_doaj_primary_oai_doaj_org_article_f19d66e553924bd2bb8b244e894f4519
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f19d66e553924bd2bb8b244e894f4519
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-33333-6
