Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
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London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Lymphatic endothelial cells (LECs) chemoattract naïve T cells and promote their survival in the lymph nodes, and can cross-present antigens to naïve CD8
+
T cells to drive their proliferation despite lacking key costimulatory molecules. However, the functional consequence of LEC priming of CD8
+
T cells is unknown. Here, we show that wh...
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Full title
Lymphatic endothelial cells prime naïve CD8+ T cells into memory cells under steady-state conditions
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TN_cdi_doaj_primary_oai_doaj_org_article_f23b98b899c044b5baa15c4c746b6da2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f23b98b899c044b5baa15c4c746b6da2
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14127-9
