Mutations in the gyrA , parC , and mexR genes provide functional insights into the fluoroquinolone-r...
Mutations in the gyrA , parC , and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in Vietnam
About this item
Full title
Author / Creator
Publisher
New Zealand: Dove Medical Press Limited
Journal title
Language
English
Formats
Publication information
Publisher
New Zealand: Dove Medical Press Limited
Subjects
More information
Scope and Contents
Contents
has many mechanisms of resistance to fluoroquinolones. The main mechanism is to change the effect of two enzymes that open the DNA helix - the enzyme DNA gyrase (
) and the topoisomerase IV (
). In addition, mutations that render the MexAB-oprM pump (
) dysfunctional, leading to its overexpression, also enhance resistance to fluoroquinolon...
Alternative Titles
Full title
Mutations in the gyrA , parC , and mexR genes provide functional insights into the fluoroquinolone-resistant Pseudomonas aeruginosa isolated in Vietnam
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f2483bca44a44b52a7d734832b48c61c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f2483bca44a44b52a7d734832b48c61c
Other Identifiers
ISSN
1178-6973
E-ISSN
1178-6973
DOI
10.2147/IDR.S147581
