The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for...
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
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Author / Creator
Wingerd, Joshua S. , Mozar, Christine A. , Ussing, Christine A. , Murali, Swetha S. , Chin, Yanni K.-Y. , Cristofori-Armstrong, Ben , Durek, Thomas , Gilchrist, John , Vaughan, Christopher W. , Bosmans, Frank , Adams, David J. , Lewis, Richard J. , Alewood, Paul F. , Mobli, Mehdi , Christie, Macdonald J. and Rash, Lachlan D.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Voltage-gated sodium (Na
V
) channels are essential for the transmission of pain signals in humans making them prime targets for the development of new analgesics. Spider venoms are a rich source of peptide modulators useful to study ion channel structure and function. Here we describe β/δ-TRTX-Pre1a, a 35-residue tarantula peptide that selec...
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Full title
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
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TN_cdi_doaj_primary_oai_doaj_org_article_f33655e710d64fada2b711f3a0de8577
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f33655e710d64fada2b711f3a0de8577
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-01129-0
