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19 results for Durek,+Thomas

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Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads
Author / Creator:Tyler, Tristan J ; Durek, Thomas ; Craik, David J
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-04, Vol.28 (7), p.3189
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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
Author / Creator:Harris, Karen S. ; Durek, Thomas ; Kaas, Quentin ; Poth, Aaron G. ; Gilding, Edward K. ; Conlan, Brendon F. ; Saska, Ivana ; Daly, Norelle L. ; van der Weerden, Nicole L. ; Craik, David J. ; Anderson, Marilyn A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-12, Vol.6 (1), p.10199-10199, Article 10199
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A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
Author / Creator:Du, Junqiao ; Yap, Kuok ; Chan, Lai Yue ; Rehm, Fabian B. H. ; Looi, Fong Yang ; Poth, Aaron G. ; Gilding, Edward K. ; Kaas, Quentin ; Durek, Thomas ; Craik, David J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-03, Vol.11 (1), p.1575-1575, Article 1575
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Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta
Author / Creator:Poon, Simon ; Harris, Karen S ; Jackson, Mark A ; McCorkelle, Owen C ; Gilding, Edward K ; Durek, Thomas ; van der Weerden, Nicole L ; Craik, David J ; Anderson, Marilyn A
Publisher:UK: Oxford University Press
Journal title:Journal of experimental botany, 2018-01, Vol.69 (3), p.633-641
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A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein
Author / Creator:Harris, Karen S. ; Guarino, Rosemary F. ; Dissanayake, Ravindu S. ; Quimbar, Pedro ; McCorkelle, Owen C. ; Poon, Simon ; Kaas, Quentin ; Durek, Thomas ; Gilding, Edward K. ; Jackson, Mark A. ; Craik, David J. ; van der Weerden, Nicole L. ; Anders, Robin F. ; Anderson, Marilyn A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-07, Vol.9 (1), p.10820-13, Article 10820
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Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme
Author / Creator:Durek, Thomas ; Torbeev, Vladimir Yu ; Kent, Stephen B.H
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2007-03, Vol.104 (12), p.4846-4851
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Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain
Author / Creator:Deuis, Jennifer R ; Wingerd, Joshua S ; Winter, Zoltan ; Durek, Thomas ; Dekan, Zoltan ; Sousa, Silmara R ; Zimmermann, Katharina ; Hoffmann, Tali ; Weidner, Christian ; Nassar, Mohammed A ; Alewood, Paul F ; Lewis, Richard J ; Vetter, Irina
Publisher:Switzerland: MDPI
Journal title:Toxins, 2016-03, Vol.8 (3), p.78
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The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
Author / Creator:Wingerd, Joshua S. ; Mozar, Christine A. ; Ussing, Christine A. ; Murali, Swetha S. ; Chin, Yanni K.-Y. ; Cristofori-Armstrong, Ben ; Durek, Thomas ; Gilchrist, John ; Vaughan, Christopher W. ; Bosmans, Frank ; Adams, David J. ; Lewis, Richard J. ; Alewood, Paul F. ; Mobli, Mehdi ; Christie, Macdonald J. ; Rash, Lachlan D.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-04, Vol.7 (1), p.974-15, Article 974
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NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency
Author / Creator:Harvey, Peta J. ; Kurniawan, Nyoman D. ; Finol-Urdaneta, Rocio K. ; McArthur, Jeffrey R. ; Van Lysebetten, Dorien ; Dash, Thomas S. ; Hill, Justine M. ; Adams, David J. ; Durek, Thomas ; Craik, David J.
Publisher:Basel: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2715
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Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe
Author / Creator:Israel, Mathilde R. ; Dash, Thomas S. ; Bothe, Stefanie N. ; Robinson, Samuel D. ; Deuis, Jennifer R. ; Craik, David J. ; Lampert, Angelika ; Vetter, Irina ; Durek, Thomas
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2020-06, Vol.8 (6), p.155
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Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling
Author / Creator:Pylypenko, Olena ; Rak, Alexey ; Durek, Thomas ; Kushnir, Susanna ; Dursina, Beatrice E ; Thomae, Nicolas H ; Constantinescu, Alexandru T ; Brunsveld, Luc ; Watzke, Anja ; Waldmann, Herbert ; Goody, Roger S ; Alexandrov, Kirill
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2006-01, Vol.25 (1), p.13-23
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Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization
Author / Creator:Rehm, Fabian B. H. ; Jackson, Mark A. ; De Geyter, Ewout ; Yap, Kuok ; Gilding, Edward K. ; Durek, Thomas ; Craik, David J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (16), p.7831-7836
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Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
Author / Creator:Yap, Kuok ; Du, Junqiao ; Rehm, Fabian B. H. ; Tang, Shyn Ric ; Zhou, Yan ; Xie, Jing ; Wang, Conan K. ; de Veer, Simon J. ; Lua, Linda H. L. ; Durek, Thomas ; Craik, David J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2021-03, Vol.16 (3), p.1740-1760
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Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET
Author / Creator:Kubota, Tomoya ; Durek, Thomas ; Dang, Bobo ; Finol-Urdaneta, Rocio K. ; Craik, David J. ; Kent, Stephen B. H. ; French, Robert J. ; Bezanilla, Francisco ; Correa, Ana M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (10), p.E1857-E1865
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Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Author / Creator:Jami, Sina ; Deuis, Jennifer R. ; Klasfauseweh, Tabea ; Cheng, Xiaoyang ; Kurdyukov, Sergey ; Chung, Felicity ; Okorokov, Andrei L. ; Li, Shengnan ; Zhang, Jiangtao ; Cristofori-Armstrong, Ben ; Israel, Mathilde R. ; Ju, Robert J. ; Robinson, Samuel D. ; Zhao, Peng ; Ragnarsson, Lotten ; Andersson, Åsa ; Tran, Poanna ; Schendel, Vanessa ; McMahon, Kirsten L. ; Tran, Hue N. T. ; Chin, Yanni K.-Y. ; Zhu, Yifei ; Liu, Junyu ; Crawford, Theo ; Purushothamvasan, Saipriyaa ; Habib, Abdella M. ; Andersson, David A. ; Rash, Lachlan D. ; Wood, John N. ; Zhao, Jing ; Stehbens, Samantha J. ; Mobli, Mehdi ; Leffler, Andreas ; Jiang, Daohua ; Cox, James J. ; Waxman, Stephen G. ; Dib-Hajj, Sulayman D. ; Neely, G. Gregory ; Durek, Thomas ; Vetter, Irina
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-04, Vol.14 (1), p.2442-2442, Article 2442
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Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors
Author / Creator:Durek, Thomas ; Shelukhina, Irina V. ; Tae, Han-Shen ; Thongyoo, Panumart ; Spirova, Ekaterina N. ; Kudryavtsev, Denis S. ; Kasheverov, Igor E. ; Faure, Grazyna ; Corringer, Pierre-Jean ; Craik, David J. ; Adams, David J. ; Tsetlin, Victor I.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-11, Vol.7 (1), p.16606-11, Article 16606
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Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase
Author / Creator:Rak, Alexey ; Pylypenko, Olena ; Durek, Thomas ; Watzke, Anja ; Kushnir, Susanna ; Brunsveld, Lucas ; Waldmann, Herbert ; Goody, Roger S. ; Alexandrov, Kirill
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2003-10, Vol.302 (5645), p.646-650
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ArticlesPeer ReviewedFull Text
Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function
Author / Creator:Jami, Sina ; Deuis, Jennifer R ; Klasfauseweh, Tabea ; Cheng, Xiaoyang ; Kurdyukov, Sergey ; Chung, Felicity ; Okorokov, Andrei L ; Li, Shengnan ; Zhang, Jiangtao ; Cristofori-Armstrong, Ben ; Israel, Mathilde R ; Ju, Robert J ; Robinson, Samuel D ; Zhao, Peng ; Ragnarsson, Lotten ; Andersson, Åsa ; Tran, Poanna ; Schendel, Vanessa ; McMahon, Kirsten L ; Tran, Hue N T ; Chin, Yanni K-Y ; Zhu, Yifei ; Liu, Junyu ; Crawford, Theo ; Purushothamvasan, Saipriyaa ; Habib, Abdella M ; Andersson, David A ; Rash, Lachlan D ; Wood, John N ; Zhao, Jing ; Stehbens, Samantha J ; Mobli, Mehdi ; Leffler, Andreas ; Jiang, Daohua ; Cox, James J ; Waxman, Stephen G ; Dib-Hajj, Sulayman D ; Neely, G Gregory ; Durek, Thomas ; Vetter, Irina
Publisher:England
Journal title:Nature communications, 2023-04, Vol.14 (1), p.2442
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ArticlesPeer ReviewedFull Text
NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na V Channel Potency
Author / Creator:Harvey, Peta J ; Kurniawan, Nyoman D ; Finol-Urdaneta, Rocio K ; McArthur, Jeffrey R ; Van Lysebetten, Dorien ; Dash, Thomas S ; Hill, Justine M ; Adams, David J ; Durek, Thomas ; Craik, David J
Publisher:Switzerland
Journal title:Molecules (Basel, Switzerland), 2018-10, Vol.23 (10)
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Native and Engineered Cyclic Disulfide-Rich Peptides as Drug Leads

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Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

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A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

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Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta

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A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

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Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme

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Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain

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The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity

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NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency

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Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe

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Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

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Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization

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Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases

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Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET

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Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function

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Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors

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Structure of Rab GDP-Dissociation Inhibitor in Complex with Prenylated YPT1 GTPase

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Pain-causing stinging nettle toxins target TMEM233 to modulate Na V 1.7 function

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NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na V Channel Potency

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