mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient and energetically costly. How cells coordinate GPX4 synthesis with nutrient availability remains unclear. In this study, we perform integrat...
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mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_f3ac49c7fb974751a3e7aab804b7d325
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3ac49c7fb974751a3e7aab804b7d325
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-21841-w
