Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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Author / Creator
Heimhalt, Maren , Berndt, Alex , Wagstaff, Jane , Anandapadamanaban, Madhanagopal , Perisic, Olga , Maslen, Sarah , McLaughlin, Stephen , Yu, Conny Wing-Heng , Masson, Glenn R , Boland, Andreas , Ni, Xiaodan , Yamashita, Keitaro , Murshudov, Garib N , Skehel, Mark , Freund, Stefan M and Williams, Roger L
Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Scope and Contents
Contents
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find that DEPTOR is a unique
partial
mTORC1 inhibitor that may have evolved to preserve feedback inh...
Alternative Titles
Full title
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
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TN_cdi_doaj_primary_oai_doaj_org_article_f3e3156092d447fd9fa28ea08dad4816
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3e3156092d447fd9fa28ea08dad4816
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.68799
