Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects du...
Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants
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England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Missense mutations of valosin-containing protein (VCP) cause an autosomal dominant disease known as inclusion body myopathy, Paget disease with frontotemporal dementia (IBMPFD) and other neurodegenerative disorders. The pathological mechanism of IBMPFD is not clear and there is no treatment. We show that endogenous VCP negatively regulates Mitofusi...
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Full title
Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants
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TN_cdi_doaj_primary_oai_doaj_org_article_f3fc780a709148e3bf4df76485d8438c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3fc780a709148e3bf4df76485d8438c
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.17834
