Structural and mutational analysis of the ribosome-arresting human XBP1u
Structural and mutational analysis of the ribosome-arresting human XBP1u
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the peptidyl transferase center where it causes a subt...
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Structural and mutational analysis of the ribosome-arresting human XBP1u
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TN_cdi_doaj_primary_oai_doaj_org_article_f441759e29854117a41889883f5b50a1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f441759e29854117a41889883f5b50a1
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.46267
