Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase i...
Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid
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Cham: Springer International Publishing
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Language
English
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Cham: Springer International Publishing
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Background
To study MMP activity in vivo in disease, several radiolabeled MMP inhibitors functioning as radiotracers have been evaluated by means of SPECT and PET. Unfortunately, most of them suffer from metabolic instability, mainly hepatobiliary clearance and insufficient target binding. The introduction of a fluorine atom into MMPIs could con...
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Full title
Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid
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TN_cdi_doaj_primary_oai_doaj_org_article_f46543465c6341a8b7a69de0fcd3d048
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f46543465c6341a8b7a69de0fcd3d048
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ISSN
2365-421X
E-ISSN
2365-421X
DOI
10.1186/s41181-018-0045-0
